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Sex-related effects too deserve attention here, particularly in the light of a very recent clinical study of DNA methylation associated with UA concentration

In colon biopsy samples from IBD patients, CD4 + T cells show markedly increased pyruvate dehydrogenase kinase (PDK) expression, and PDK4 inhibition alleviates intestinal inflammation in a DSS-induced murine colitis model (210)

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Eur J Pharmacol 667(1-3):322329 B Klicek R, Kolenc D, Suran J et al (2013) Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability

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